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JXB Advance Access originally published online on May 31, 2008
Journal of Experimental Botany 2008 59(10):2757-2767; doi:10.1093/jxb/ern133
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© 2008 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. This paper is available online free of all access charges (see http://jxb.oxfordjournals.org/open_access.html for further details)

RESEARCH PAPER

Identification of auxins by a chemical genomics approach

May Christian1, William B. Hannah1, Hartwig Lüthen2 and Alan M. Jones1,*

1Departments of Biology and Pharmacology, The University of North Carolina at Chapel Hill, NC 27599-3280, USA
2Biozentrum Klein Flottbek und Botanischer Garten, Ohnhorststrasse 18, 22609 Hamburg, Germany

* To whom correspondence should be addressed. E-mail: alan_jones{at}unc.edu

Thirteen auxenic compounds were discovered in a screen of 10 000 compounds for auxin-like activity in Arabidopsis roots. One of the most potent substances was 2-(4-chloro-2-methylphenoxy)-N-(4-H-1,2,4-triazol-3-yl)acetamide (WH7) which shares similar structure to the known auxenic herbicide 2,4-dichlorophenoxyacetic acid (2,4-D). A selected set of 20 analogues of WH7 was used to provide detailed information about the structure–activity relationship based on their efficacy at inhibiting and stimulating root and shoot growth, respectively, and at induction of gene expression. It was shown that WH7 acts in a genetically defined auxin pathway. These small molecules will extend the arsenal of substances that can be used to define auxin perception site(s) and to dissect subsequent signalling events.

Key words: Auxin, 2,4-D, growth control, sensitivity, structure–activity

Received 7 February 2008; Revised 31 March 2008 Accepted 14 April 2008


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