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JXB Advance Access originally published online on January 22, 2008
Journal of Experimental Botany 2008 59(2):225-234; doi:10.1093/jxb/erm300
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© 2008 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. This paper is available online free of all access charges (see http://jxb.oxfordjournals.org/open_access.html for further details)

RESEARCH PAPER

HDA6 is required for jasmonate response, senescence and flowering in Arabidopsis

Keqiang Wu1,*, Lin Zhang2, Changhe Zhou2, Chun-Wei Yu1 and Vijaya Chaikam2

1Institute of Plant Biology, College of Life Science, National Taiwan University, Taipei 10617, Taiwan
2Department of Biology, West Virginia University, Morgantown, WV 26506-6057, USA

* To whom correspondence should be addressed. E-mail: kewu{at}ntu.edu.tw

Post-translational modifications of histones, including acetylation, play a key role in modulating dynamic changes in chromatin structure and gene activity. Histone acetylation is modulated through the action of histone acetyltransferases and deacetylases. HDA6 is a RPD3-type histone deacetylase in Arabidopsis. The Arabidopsis HDA6 mutant, axe1-5, and HDA6 RNA-interfering (HDA6-RNAi) plants displayed higher levels of acetylated H3 compared with wild-type, suggesting that HDA6 affects histone acetylation levels globally. The expression of the jasmonate responsive genes, PDF1.2, VSP2, JIN1, and ERF1, was down-regulated in axe1-5 and HDA6-RNAi plants. Furthermore, axe1-5 and HDA6-RNAi plants displayed increased leaf longevity compared with the wild type. The expression of the senescence-associated genes, SAG12 and SEN4, was down-regulated in the axe1-5 and HDA6-RNAi plants. In addition, axe1-5 and HDA6-RNAi plants displayed late-flowering. The expression of FLC was up-regulated and hyperacetylated in axe1-5 and HDA6-RNAi plants, suggesting that HDA6 is required to deacetylate FLC chromatin and thereby repress its expression. Our results suggest that HDA6 is involved in jasmonate response, senescence, and flowering in Arabidopsis.

Key words: HDA6, flowering, histone deacetylases, jasmonic acid, senescence

Received 3 September 2007; Revised 3 November 2007 Accepted 5 November 2007


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