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JXB Advance Access published online on May 7, 2004
Journal of Experimental Botany, doi:10.1093/jxb/erh136
© 2004 by Oxford University Press
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Received December 4, 2003; accepted February 24, 2004
© 2004 Society for Experimental Biology

FOCUS PAPER

Molecular analysis and control of cysteine biosynthesis: integration of nitrogen and sulphur metabolism

Holger Hesse 1*, Victoria Nikiforova 1, Bertrand Gakière 1, and Rainer Hoefgen 1

1 Max-Planck-Institut für Molekulare Pflanzenphysiologie, Department of Molecular Physiology, Am Muehlenberg 1, D-14476 Golm, Germany

* To whom correspondence should be addressed. E-mail: hesse{at}mpimp-golm.mpg.de.


  Abstract

Since cysteine is the first committed molecule in plant metabolism containing both sulphur and nitrogen, the regulation of its biosynthesis is critically important. Cysteine itself is required for the production of an abundance of key metabolites in diverse pathways. Plants alter their metabolism to compensate for sulphur and nitrogen deficiencies as best as they can, but limitations in either nutrient not only curb a plant’s ability to synthesize cysteine, but also restrict protein synthesis. Nutrients such as nitrate and sulphate (and carbon) act as signals; they trigger molecular mechanisms that modify biosynthetic pathways and thereby have a profound impact on metabolite fluxes. Cysteine biosynthesis is modified by regulators acting at the site of uptake and throughout the plant system. Recent data point to the existence of nutrient-specific signal transduction pathways that relay information about external and internal nutrient concentrations, resulting in alterations to cysteine biosynthesis. Progress in this field has led to the cloning of genes that play pivotal roles in nutrient-induced changes in cysteine formation.

Key words: Cysteine biosynthesis, nitrate assimilation, O-acetylserine (thiol)lyase, serine acetyltransferase, sulphate, transcriptomics.


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