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JXB Advance Access published online on November 15, 2004
Journal of Experimental Botany, doi:10.1093/jxb/eri011
© 2004 by Oxford University Press
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Received May 20, 2004
Accepted August 30, 2004

Metabolomics and Metabolic Profiling Special Issue Article

Enzymes, metabolites and fluxes

David A. Fell 1*

1 School of Biological and Molecular Sciences, Oxford Brookes University, Headington, Oxford, OX3 0BP, UK

* To whom correspondence should be addressed.
David A. Fell, E-mail: dfell{at}brookes.ac.uk


  Abstract

Aspects of metabolic control theory and experiments from metabolic biochemistry are reviewed in order to deduce the circumstances in which experimental studies involving metabolomics have the greatest chance of success. It is concluded that metabolic changes effected mainly through a single enzyme are those most likely to lead to large changes in metabolite concentrations. Metabolic changes brought about through signal transduction mechanisms will tend to result in relatively much smaller adjustments in metabolite concentrations, whilst allowing significant changes in metabolic rates.

Keywords: Control coefficient; metabolic control analysis; metabolomics; multi-site modulation; proportional activation.
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